Season five of Murdoch Mysteries opens in unfamiliar territory, as Detective William Murdoch (Yannick Bisson) leaves Toronto to try his luck while the Klondike Gold Rush in the Yukon winds down. Suspended for interfering in an investigation, on the run for surreptitiously freeing a murderer to make amends, and nursing …

脱衣舞女瑞秋•威尔森（Cherish Lee 切瑞希•李 饰）遭遇一场严重车祸，经医护人员的全力抢救，瑞秋侥幸生还。但不久她便发现，似乎死神（Adam Fortin 亚当•福汀 饰）并不愿就此罢休，而是紧随其后伺机夺取她的性命。惶恐的瑞秋向护士求救，结果被当作精神病人送往某个精神康复所。在这个破败阴森的场所，瑞秋发现周遭还住着5个与其有着同样经…